After beating Munster in Dublin last week, Leinster face a second interpro in six days as they travel to Connacht on Friday night (19:45 GMT).
The team, however, will be almost entirely different with fly-half Joey Carbery the only player who started in the Aviva Stadium last Saturday to go again at the Dexcom.
Leo Cullen has selected a whole new pack with Max Deegan coming in to captain the side from the back row.
Experienced wing Jordan Larmour will make his return from injury in the number 11 jersey, while centre Connor Fahy makes his debut.
Should he be called upon from the bench, prop Alex Mullan will also make his provincial bow.
Hosts Connacht have similarly rung the changes, making 12 alterations from their comfortable win over Zebre last week.
With eight players away on international duty, skipper Paul Boyle, prop Finlay Bealham and centre Cathal Forde are the only starters retained.
Connacht: Ioane; Bolton, Devine, Forde, Ryan; Naughton, Blade; Van Wyk, Heffernan, Bealham, Murphy, O’Connor, O’Brien, Connors, Boyle (capt).
Replacements: Victory, Cahir, Barrett, Murray, Hurley-Langton, Reilly, Treacy, Gilbert.
Leinster: Lawlor; Kenny, Fahy, Tector, Larmour; Carbery, Gunne; Usanov, McCarthy, N Smyth, Deeny, Spicer, Deegan (capt), Penny, Culhane.
Replacements: S Smyth, Dooley, Mullan, O’Tighearnaigh, Soroka, Foley, Gabriel, Mangan